Study on 58 co-infection HCV/HIV patients and 140 simple HIV infection patients in Department of Infectious Diseases - Hospital No.103. The result showed that: the percentage of patients with clinical symptoms of liver in group of co-infection with HCV/HIV is low (yellow skin, yellow eyes, dark urine 13.8 percent, fatigue 8.6 percent, anorexia 6.9 percent, painright upper quadrant 5.2 percent, nausea 3.4 percent, hepatomegaly 3.4 percent). Increase in ALT, AST and total Bilirubin is less common symptoms in HCV/HIV co-infection group, respectively 25.9 percent, 29.3 percent and 10.3 percent. However, increased GGT is a fairly common symptom (55.7 percent). No statistically significant difference in clinical symptoms, liver enzyme tests, bilirubin in the groups with and without HCV co-infection.