Một số đặc điểm lâm sàng, cận lâm sàng và đột biến jak2v617f trên bệnh nhân tăng tiểu cầu nguyên phát

• Tác giả: Thị Thu Hiền Nguyễn, Thị Xinh Phan
• Ngôn ngữ: vie
• Ký hiệu phân loại: 616.151 *Diseases of erythrocytes
• Thông tin xuất bản: Tạp chí Y học Việt Nam, 2012
• Mô tả vật lý: 85-89
• Bộ sưu tập: Metadata
• ID: 635367

Tóm tắt

Objectives: Determine the clinical, paraclinical features and implications of the JAK2V617F mutation in essential thrombocythemia. Method and patients: A retrospective study of 122 patients with the diagnostic of essential thrombocythemia according to WHO 2008 criteria at the Blood transfusion and Hematology hospital of Ho Chi Minh city from June 2009 to May 2011. Results: A total of 122 patients are diagnosed as essential thrombocythemia with the mean age 53 years (range 24 - 93 years), the typical sign is high platelet count. The ratio of male and female is 0.37/1. The common complications are thrombosis (38.52 percent) and hemorrhage (15.57 percent). Mean platelet count is 1300 x 109/L. The rate of JAK2V617F mutation is detected about 59.02 percent. The patients with mutation are older and have higher hemoglobin concentration and white blood cell count (p0.05) but lower platelet count than ones without mutation. Conclusions: The detection of JAK2V617F mutation has a very important role in diagnosis of myeloid proliferative disorders.