The hazard assessment of chemical reactions is essential requirements to design and safe operation in the chemical manufacturing process. The use of software and other screening methods in the study to reduce the number of experiments, saving time and cost. By CHETAH software, the researchers assessed the hazard levels of heat of alkyd resins synthesis reaction, is the prerequisite for assessing the hazard level of the chemical reactions chemical manufacturing industry application for caculation, design paInts, storage, transportation,... to minimize the risk.