Objectives: In recent years, BNP and NT-proBNP is emerging as biomarkers play a key role in the treatment and prognosis of cardiovascular disease has been recognized in the diagnosis of heart failure and now this biomarker important in assessing cardiac dysfunction and prognostic value in patients with acute myocardial infarction, the domestic and intemational research shows: that BNP and NT-proBNP increased rapidly and soon provide information on prognosis so we also aims to study the role of NT-proBNP in the short-term prognosis of acute myocardial infarction. Subjects and Methods: Research cohort study using questionnaires and serum samples of patients admitted to hospital with a diagnosis of acute coronary syndrome without ST segment at Cho Ray Hospital in the period from January 9-2010 to 6 2011 patients or = 18 years of age. Results: Sample of 96 patients completed the study. The average age 67.99 + or - 11.03 years, women accounted for 45.8 percent of men and women almost equal rate, characteristics serum NT-proBNP concentrations survey (time 1) now enter higher levels of NT-proBNP (2) a week later, the concentration of NT-proBNP (1.2) higher than the group of patients 65 years of age, NT-proBNP concentrations (1.2) are found in the group of patients with Killip-grade or = II statistically significant with p 0.001, serum NTproBNP concentrations are closely related to the scale of TlMI risk (p 0.001). NT-proBNP serum concentrations related mortality patients with myocardial infarction without ST difference with p 0.001, left ventricular ejection fraction is closely related to the concentration of NT-proBNP. Conclusions: Our study showed increased levels of NT-proBNP concerning money short-terms of death myocardial infarction patients without ST segment and stable angina.