Designed for the demanding applications in analyzing environmental, clinical and other high matrix samples, the CRC-ICP-MS system provides the best detection limits for determination of trace elements in the toughest sample types, ranging from wastewater, seawater, sediment to foods and biological samples. In this work, the direct and simultaneous determination of multi elements in high matrix samples by CRC-ICP-MS technique with remove polyatom interferences by kinetic energy discrimination have been investigated.