Objective: To assess level of Osteocalcin, Beta-Crosslap serum and correlation between the biochemical serum with age, menopausal time, BMD in postmenopausal women. Subject and method: Cross-sectional descriptive. 139 women were distributed: patient group include 101 postmenopausal women and the control 38 young healthy women who are 2035 years old. All women were examined BMD by DEXA and investigated OC and BC serum based on "sandwish" theory. Results: Mean age of postmenopausal women 61.6 + or - 8.5 years old. Rate of obesity in patient group 31.7 percent. Mean menopausal age of postmenopausal women 49.5 + or - 2.9 years old. In postmenopausa1 osteoporotic women OC serum 18.02 + or - 7.09 ng/ml and BC serum 0.64 + or - 0.30ng/ml are higher in postmenopausal women who don't have osteoporosis, significantly, p0.05. There are weak contrary correlation between OC va Be serum with BMD of femoral neck (respectively r