Methods: 65 inpatients and outpatients in National hospital of tropical disease (NHTD) were enrolled in this study from February 2011 to September 2011. Clinical, laboratory data were collected at admission the patient began. HBV-DNA quantiative was made by Real-time PCR. Results: - There was no correlation between virus load with some clinical (fatigue, anorexia, jaundice, hepatomegaly...) and laboratory enzyme ALT, ratio Prothrombin
- There was relation between virus load with HBeAg and AntiHBe. The highest rate of HBeAg (+) in the group of patients with highest virus load 10 exponent 8 copies / ml (72.2 percent). The highest rate of AntiHBe (+) in the group of patients with virus load an average of 10 exponent 2 to 10 exponent 5 copies/ml (81.8 percent) and lowest in the group with highest virus load (33.3 percent), the significant difference statistics with p 0.05.