Introduction: Drug addiction, particularly heroin addiction is a social evil. It has deeply affect to patients, families and society. Numbers person drug addicts has trends increasing. Objective: To study clinical features of heroin addiction syndrome. Patients and Method: including 59 male patients, accordinl{ to the heroin addict diagnosis standard of American psychiatry Assembly in 1994 (DSM-IV), inpatient treatment at a mental hospital in Hai Phong, aged from 18 to 58 years old. it is prospective study, cross, analyze each of the typical case. Results: heroin addiction mainly moderate 64.40 percent, anxiety disorders was 88.14 percent, 55.9 percent emotional disorders, disorders of consciousness was: 27.12 percent, consciousness disorder was 32,20 percent, behavioral disorder was 89.83 percent. Conclusion: The study of clinical features of heroin addiction syndrome is essential in the treatment of drug addiction.