The consecutive patients were monitored serum creatinine levels before and after the first 24 hours percutaneous coronary intervention at the Vietnam Heart Institute-Bachmai Hospital from 08-2008 to 02-2009. Some risk factors associated with Contrast Induced Nephropathy (CIN) has been studied and analyzed. Results: 40 patients were identified as CIN (increased serum creatinine levels compared to 44,2 umol/l before intervention) reached 7,8 percent. The average serum creatinine levels after the first 24 hours procedures was higher than average serum creatinin levels before (p 0,001). Some risk factors involving: using ionizing contrast (p 0,001), the age of patients or = 70 (p 0,05), cardiogenic shock (p 0,001), heart failure NYHA level III-IV (p 0,05), left ventricular ejection fraction 29 percent (p 0,01), renal disease (p 0,001), hypertension (p 0,05).