The use of natural products as anti-malaria drugs was confirmed by many scientists and finding out new resources of natural compounds was the goal of many researches. In this paper, the authors collected 20 plants in Zanthoxylum genus, Citrus genus (Rutaceae family), curcuma genus (Zingiberaceae family), Cinanamomum genus (Lauraceae family), Aglaia genus (Meliaceae family) and Piper genus (piperaceae family) in Vietnam. A total of 14 extractions (NAF01NAF14) and 7 compounds (Cinnamaldehyde (1), 2-Hydroxycinnamaldehyde (2), ,piperin (3), 4-Allylpyrocatechol (4), Isoimperatorin (5), Odorin (6), va Odorinol (7)) were purified NAF03, NAF07, NAF09 had powerful killing effects, almost 100 percent knocked down after 60 minutes exposed and died after 24 hours. NAF07 combined with permethrin had better resonance in killing and repellent effect than single ones.