The study was conducted on 65 patients with generalized vitiligo determined 9 cytokine (lL-2, IL-4, IL-5, IL-10, IL-12, IL-13, GM-CSF, IFN-gamma, and TNF-alpha) in serum before and after treatment by Davobet (30 patients) and Vitiskin (35 patients). The result showed that Daivobet group has decreased 5 cytokine (lL-5, IL-12, GM-CSF, IFN-gamma and TNF-alpha) after treaetment, but cytokines: IL-2, IL-4, IL10, IL-13 has unchanged after treatment. The Vitiskin group has unchanged of 9 cytokine after treatment.