Vinblastine, a clinical anti-cancer drug, is synthesized from catharanthine and vindoline via 3',4'anhydrovinblastine which is a key intermediate in the synthesis of vinblastine. This intermediate is obtained by coupling catharanthine and vindoline through two methods. The first coupling method is an application of PotierPolonovski reation (total yield: 12 percent) and the other is a Fe(III)-promoted coupling reaction (total yield: 30 percent). The structure of the obtained compounds have been confirmed by IR, 1H, 13C-NMR, MS spectra, and [alpha]o.