Introdution: differentiated thyroid carcinoma is common in young women, the disease is usually confirmed by histological examination, but there should be some cases immunohistochemistry (IHC) staining to determine the type, the level of invasion and malignancy grade to help guide the prognosis and follow-up after surgery. Research Objective: Determine rates revealed and the value of some markers of IHC in differentiated thyroid carcinoma. Materials and methods: It is conducted in Center of research and . e,rly detection of cancer (CREDCA) with 96 cases of differentiated thyroid carcinoma is processed specimens after surgery. Diagnosis on the template dye H.E. Dye IHC with markers: TGB, TTF-1, CK7, EMA, p53 and Ki-67. Results: Differentiated thyroid carcinoma is common in young women (20-29 years), mainly papillary thyoid carcinoma. 91.67 percent were positive for TGB, TTF-1 positive rate is low (31.25 percent), CK7 is 97.92 percent, EMA is 76.04 percent, Ki-67 has a low positive rate (27.08 percent), negative for p53. Conclusion: The immunohistochemical staining is confirm differentiated thyroid carcinoma cell proliferation index is low, less mutant p53 tumor suppression, so the overall low malignancy and good prognosis. Also, immunohistochemical staining is useful in distinguishing cancer cells and non-cancer cells, and assess the invasions of cancer cells.