The authors analyzed the result treatment of mediastinal cancer patients by the chemoradiotherapy combination in Hai Phong from 2007 to 2011. Method: 27 patients with the anatomo-patho diagnosis of mediastinal cancer were treated by the regime chemo-radiotherapy in Hai Phong from 2007 to 2011. Result: A total of 27 patients, men/women rate 4,4/1, average age 60,1. The prevalent cause is the lung cancer metastatic mediastinal lymph node - 71,1 percents. The objective response of treatment was 100 percent. Median survival was 33,4 months and 1-year survival rate of 81,6 percent. Leukopenia rate was 5 percent and another toxicities are acceptable side effects. Conclusion: Treatment chemo-radiotherapy combination for mediastinal cancer is the method, which does not have any other choice in Hai Phong with the acceptable side effects and the respective and feasible results.