Biofilms constitute 80 % of all nosocomial infections associated with invasive medical devices. Polydimethylsiloxane, a highly elastic, inert, non-reactive, biocompatible silicone polymer is widely used as implant biomaterial due to its non-toxic and low-immunogenic nature. Owing to its hydrophobicity, PDMS suffers from microbial adhesion. Inhibition of biofilm formation on PDMS surfaces is imperative to prevent morbidity, mortality and replacement of implants. The present study investigates the efficacy of capsaicin (0.5 % w/v) loaded PDMS as a broad spectrum antimicrobial surface against Staphylococcus aureus, Escherichia coli and Candida albicans. Capsaicin exhibited minimum inhibitory concentration of 1024 μg mL