Mutational and co-mutational landscape of early onset colorectal cancer.

• Tác giả: Kristin Alfaro, Jumanah Yousef Alshenaifi, Arvind Dasari, Andy Futreal, Ryan Huey, Scott Kopetz, Giulia Maddalena, Van Karlyle Morris, Michael J Overman, Christine Parseghian, Kanwal P Raghav, John Paul Shen, Guglielmo Vetere, Eduardo Vilar, Michael G White, Jason Willis, Robert Wolff, Y Nancy You, Mahmoud Yousef
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.5265 Astrology
• Thông tin xuất bản: England : Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals , 2025
• Bộ sưu tập: NCBI
• ID: 637968

Tóm tắt

 INTRODUCTION: Colorectal cancer (CRC) incidence and mortality before 50 have been rising alarmingly in the recent decades. METHODS: Using a cohort of 10,000 patients, this study investigates the clinical, mutational, and co-mutational features of CRC in early-onset (EOCRC, <
  50 years) compared to late-onset (LOCRC, ≥ 50 years). RESULTS: EOCRC was associated with a higher prevalence of Asian and Hispanic patients, rectal or left-sided tumors (72% vs. 59%), and advanced-stage disease. Molecular analyses revealed differences in mutation patterns, with EOCRC having higher frequencies of CONCLUSION: This study highlights the significance of age-specific molecular profiling, offering insights into the unique biology of EOCRC and potential clinical applications.