The production of bio-based fine chemicals is increasingly important to address fossil energy shortages, climate change, and other environmental issues. Using abundant and renewable bioresource as starting material to manufacture bio-based fine chemicals will achieve a green circular economy. 5-Formyl-2-furoic acid (FFCA) and 2,5-furandicarboxylic acid (FDCA) have broad application prospects in fuels, chemical intermediates, polymers and pharmaceuticals. In this research, a green and effectual biotransformation process was built to manufacture FFCA and FDCA from biomass-derived furan-2,5-dicarbaldehyde (DFF) in DMSO-H