Background: Acinetobacter baumannii has emerged as one of the most troublesome pathogens for healthcare institutions globally and is becoming a multi-drug resistance as well as a common cause for hospital infections. Objectives: To study the resistance of A baumannii isolated in seven hospitals in the North, Centre and South of Vietnam. Methods: Doing research with the participation of the clinical microbiological laboratories of seven hospitals. A. baumannii strains were isolated from all clinical specimens collected from the in-patients. A. baumannii after being identified as antibiotic resistance was used with folded paper techniques to determine the diffusion resistance. Results: From January 1, 2011 to December 31, 2011, the authors collected 3,232 A. baumannii samples in seven level-l hospitals, representing for three areas in Northem, Cenral and Southern Vietnam. The results showed that there were 13 groups of 15 antibiotics tested having resistance rates above 70 percent. The Carbapenem group had high resistance rates (76.5 percent for imipenem, 81.3 percent for meropenem), over 80 percent of cephalosporin resistance, including resistance against cefepim of 83.9 percent, against ceftazidin of 86.7 percent, against cefotaxime of 88 percent, and ceftriaxone 93.1 percent. High sensitivity antibiotic Colistin and also the final selection of resistance started against as much as 15.7 percent. Ratio of resistants against over 3 types of antibiotics accounted for 87.7 percent
that against over 10 types of antibiotics was 42.7 percent, and 100 percent of sensitivity rate was only 5 percent. There are differences in antibiotic resistance by regions, clinical departments, and ages of children and adults with p 0.05. Conclusion: There is increasing resistance of Abaumannii in seven hospitals of three different regions in Vietnam. Resistance rate varies from regions, ages and clinical departments. It is necessary to have an infection control policy and antibiotic
stewardship strategy at all hospital, regional and national levels.