Light-activated nanocomposite thin sheet for high throughput contactless biomolecular delivery into hard-to-transfect cells.

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Tác giả: Donia Dominic, Kavitha Illath, Srabani Kar, Hima Harshan Padma, Tuhin Subhra Santra

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : The Analyst , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 641470

 High throughput intracellular delivery of biological macromolecules is crucial for cell engineering, gene expression, therapeutics, diagnostics, and clinical studies
  however, most existing techniques are either contact-based or have throughput limitations. Herein, we report a light-activated, contactless, high throughput photoporation method for highly efficient and viable cell transfection of more than a million cells within a minute. We fabricated reduced graphene oxide (rGO) nanoflakes that was mixed with a polydimethylsiloxane (PDMS) nanocomposite thin sheet with an area of 3 cm
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