OBJECTIVE: To determine if the SARC-F tool, used to screen for sarcopenia risk, can also predict mild cognitive impairment (MCI) diagnosed with the Montreal Cognitive Assessment (MoCA) tool. METHODS: This is a sub-analysis of data from a cross-sectional study carried out in postmenopausal women from Latin America (nine countries) in which sociodemographic, clinical, and anthropometric data were collected, and the SARC-F and MoCA tools administered. From the original sample of 1185 women, analysis was performed only among the 772 with natural menopause. RESULTS: Overall, mean age, body mass index and years of education were 56.9 years, 26.8 kg/m CONCLUSION: This study suggests that the SARC-F questionnaire, used to assess sarcopenia risk, could also predict the presence of MCI in postmenopausal women. There is a need for more research to support our preliminary findings.