First generation vanadium-based PTEN inhibitors: Comparative study in vitro and in vivo and identification of a novel mechanism of action.

• Tác giả: George Aggelis, Katerina Antoniou, Paschalis-Thomas Doulias, Eleni Iordanidou, Themistoklis A Kabanos, Konstantina-Danai Karagkiozeli, Anastasios D Keramidas, Charalampos Labrakakis, George Leondaritis, Antonios E Nadalis, Michael G Papanikolaou, Periklis Pappas, Kyriaki Premeti, Vasiliki Syropoulou, Dimitra Tsipa
• Ngôn ngữ: eng
• Ký hiệu phân loại: 507.8 Use of apparatus and equipment in study and teaching
• Thông tin xuất bản: England : Biochemical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 641700

Tóm tắt

PTEN, a tumor suppressor phosphatase, regulates cellular functions by antagonizing the growth promoting PI3K/Akt/mTOR pathway through the dephosphorylation of the second messenger PIP