Preclinical models of soft tissue sarcomas - generation and applications to enhance translational research.

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Tác giả: Valerie G Brunton, Molly R Danks, Paul H Huang, William G J Kerrison, Piotr J Manasterski, Javier Martin-Broto, Jose L Mondaza-Hernandez, David S Moura, Sandro Pasquali, Silvia Stacchiotti, Nadia Zaffaroni

Ngôn ngữ: eng

Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons

Thông tin xuất bản: Netherlands : Critical reviews in oncology/hematology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 641705

Soft tissue sarcomas (STS) represent a large group of rare and ultra-rare tumors distinguished by unique morphological, molecular and clinical features. Patients with such rare cancers are generally underrepresented in clinical trials which has limited the introduction of new treatment options and subsequent improvement of patient outcomes. Preclinical models of STS that recapitulate the human disease can aid progress in identifying new effective treatments. However, due to the rarity of these tumors there are limited STS models available. Here we review the existing preclinical models of STS, including patient-derived cell lines and organoids, patient-derived xenografts and genetically engineered mouse models. We discuss the advantages and disadvantages of the different models and describe to what extent they have aided clinical translation. Finally, we consider what can be done in the future to enhance their predictivity in the preclinical setting.
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