Cortical acetylcholine response to deep brain stimulation of the basal forebrain in mice.

• Tác giả: David T Blake, Jamal Bogan, Sergei A Kirov, Philip O'Herron, Tucker Oliver, Khadijah Shanazz, Jeremy Sword, Alvin Terry, Fernando L Vale, Kun Xie
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of neurophysiology , 2025
• Bộ sưu tập: NCBI
• ID: 641757

Tóm tắt

Deep brain stimulation (DBS) using electrical stimulation of neuronal tissue in the basal forebrain to enhance release of the neurotransmitter acetylcholine is under consideration to improve executive function in patients with dementia. Although some small studies indicate a positive response in the clinical setting, the relationship between DBS and acetylcholine pharmacokinetics is incompletely understood. We examined the cortical acetylcholine response to different stimulation parameters of the basal forebrain. Two-photon in vivo imaging was combined with deep brain stimulation in C57BL/6J mice. Stimulating electrodes were implanted in the subpallidal basal forebrain, and the ipsilateral somatosensory cortex was imaged. Acetylcholine activity was determined using the GRAB