Expression and function of interferon lambda receptor 1 variants.

• Tác giả: Eric G Meissner, Laura A Novotny
• Ngôn ngữ: eng
• Thông tin xuất bản: England : FEBS letters , 2025
• Bộ sưu tập: NCBI
• ID: 641773

Tóm tắt

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.