Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends Upon Baseline Tissue Oxygenation.

• Tác giả: Noah J Daniel, David J Gladstone, Jiang Gui, P Jack Hoopes, Arthur F Petusseau, Brian W Pogue, Wilson A Schreiber, Austin M Sloop, Jacob P Sunnerberg, Harold M Swartz, Armin D Tavakkoli, Sergei A Vinogradov, Rongxiao Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 665.823 Oxygen
• Thông tin xuất bản: United States : International journal of radiation oncology, biology, physics , 2025
• Bộ sưu tập: NCBI
• ID: 641807

Tóm tắt

PURPOSE: This study aimed to assess the impact of tissue oxygen levels on transient oxygen consumption induced by ultra-high dose rate (UHDR) electron radiation in murine flank and to examine the effect of dose rate variations on this relationship. METHODS AND MATERIALS: Real-time oximetry using the phosphorescence quenching method and Oxyphor PdG4 molecular probe was employed. Continuous measurements were taken during radiation delivery on a UHDR-capable Mobetron linear accelerator. Oxyphor PdG4 was administered into the subcutaneous tissue of the flank skin 1 hour before irradiation. Skin oxygen tension (pO RESULTS: The decrease in pO CONCLUSIONS: The results show significant differences in the radiation-chemical effects of UHDR radiation between hypoxic and well-oxygenated tissues. Similar trends between earlier published in vitro and in vivo experiments presented herein suggest the chemical mechanisms driving the dependencies of g