First-In-Human Rapid Removal of Circulating Tumor Cells in Solid Metastatic Neoplasia by Microbind Affinity Blood Filter.

• Tác giả: Sanja Ilic, Vedran Premuzic
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: Switzerland : Blood purification , 2025
• Bộ sưu tập: NCBI
• ID: 641862

Tóm tắt

INTRODUCTION: We conducted a first-in-human trial evaluating safety and the potential for combined pathogen and circulating tumor cell (CTC) removal in patients with solid metastatic cancers. METHODS: The Seraph procedure was performed at a hemodialysis clinic on 10 consecutive patients with metastatic cancer whose liquid biopsy was positive for the epithelial cell adhesion molecule. All the patients exerted positive bacterial or fungal isolates. RESULTS: We have demonstrated the ability of Seraph100® Filter to remove both pathogens and CTCs, with median reduction of 71% within 120 min, from patient blood. CONCLUSION: High-yield CTC clearance could potentially benefit patients in diagnostic and personalized treatment of cancer to be elucidated in further research.