Clinical outcomes of patients diagnosed with

• Tác giả: Aref Al-Kali, Hassan Alkhateeb, Anmol Baranwal, Kebede Begna, Kurt Bessonen, James Foran, Patricia Greipp, Rong He, Mehrdad Hefazi-Torghabeh, William J Hogan, Yazan Jabban, Dragan Jevremovic, Abhishek Mangaonkar, Jeanne Palmer, Mrinal Patnaik, Antoine N Saliba, Mithun Shah, David Viswanatha, Mahmoud Yacout
• Ngôn ngữ: eng
• Ký hiệu phân loại: 023.2 Professional positions
• Thông tin xuất bản: United States : Leukemia & lymphoma , 2025
• Bộ sưu tập: NCBI
• ID: 641883

Tóm tắt

SETBP1 mutations (m) have been previously reported in myeloid neoplasms and are associated with poor prognostic co-mutations and cytogenetic abnormalities. We retrospectively analyzed the charts of 113 patients diagnosed with myeloid neoplasms with SETBP1m. The most common diagnosis was MDS (31%). Cytogenetics were abnormal in 51 cases (46.4%), with monosomy 7 being the most common (41.1%). The most frequent co-mutations were ASXL1 (71.7%), SRSF2 (46.9%), TET2 (20.4%). Higher SETBP1m VAF was associated with proliferative features (