Wound infections are characterized by the invasion of microorganisms into bodily tissues, leading to inflammation and potentially affecting any type of wound, including surgical incisions and chronic ulcers. If left untreated, they can delay recovery and cause tissue damage. Healthcare providers face challenges in treating these infections, which necessitate efficient treatment plans involving microbiological testing and clinical evaluation. The effectiveness of conventional treatments like antibiotics is limited by resistance. Various forms of nanotechnology have been developed, each exhibiting unique properties that address particular issues with conventional therapies. Among all the Nanocarriers, zinc oxide nanoparticles (ZnO NPs), offer promising treatments for persistent wound infections. ZnO NPs possess strong antibacterial, antioxidant, anti-inflammatory, and anti-diabetic properties, making them suitable for wound care applications. These nanoparticles can be produced economically and environmentally using green synthesis techniques that minimize toxicity and are biocompatible. While chemical and physical techniques offer precise control over nanoparticle characteristics, they often involve hazardous substances and energy-intensive procedures. The antibacterial qualities, low toxicity, and biological compatibility of green-synthesized ZnO NPs make them a promising treatment for wound infections. Their use in scaffolds, drug delivery systems, and wound dressings provides a viable approach to combat antibiotic resistance and enhance wound treatment outcomes. Furthermore research is necessary to fully realize the benefits of ZnO NPs in clinical practice.