Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.

• Tác giả: Sarah Bertrand, Michelle C D Bridi, Altagracia Contreras, Sujatha Kannan, Grace Kim, Alfredo Kirkwood, Rachel A Lee, Nancy Luo, Benjamin J Menarchek, Cristian Moreno, Caroline O'Ferrall, Ruchit Patel, Bryan Rodriguez, Daniel Severin, Christian Wesselborg
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 641994

Tóm tắt

Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested whether E/I regulation, rather than the overall E/I ratio, is disrupted in two ASD-related mouse lines: