INTRODUCTION: Endometrial cancer (EC) is the fourth most common cancer in women worldwide. The quality of care for EC patients may vary depending on the treatment center volume. The present study aimed to investigate the impact of center volume on the survival of EC patients. METHODS: This multicenter retrospective study analyzed a large cohort of EC patients with type 1 and type 2 tumors treated between 2001 and 2020 in France. The study analyzed the impact of center volume on overall survival, as well as the impact of other factors such as age, FIGO stage, lymph node involvement, laparoscopic surgery, and overall recurrence. RESULTS: The study found that treatment center volume had a significant impact on the overall survival of type 1 EC patients but not on type 2 EC patients. Other factors such as age, FIGO stage, lymph node involvement, laparoscopic surgery, and overall recurrence also impacted survival. CONCLUSION: Our study provides important insights into the quality of care for EC patients in France. The study's results highlight the impact of treatment center volume and other factors on survival and underscore the importance of high-quality care for all EC patients.