TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6.

• Tác giả: Jing Cao, Shi-Yue Chen, Jian-Min Li, Zhi-Xiao Li, Xiu-Hua Ren, Tian-En Si, Song-Xue Su, Hui-Rui Wu, Qing-Qing Yang, Wei-Dong Zang, Jing-Jing Zhang, Meng-Ya Zhang, Sen Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.133349 Aerospace engineering
• Thông tin xuất bản: United States : The Journal of biological chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 642062

Tóm tắt

Chemotherapy-induced neuropathic pain poses significant clinical challenges and severely impacts patient quality of life. Sodium ion channels are crucial in regulating neuronal excitability and pain. Our research indicates that the microRNA-30b (miR-30b) in rat dorsal root ganglia (DRG) contributes to chemotherapy-induced neuropathic pain by regulating the Nav1.6 protein. Additionally, ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a crucial role in pain generation by altering gene expression. We established a chemotherapy-induced neuropathy model using intraperitoneal oxaliplatin (OXA) injections and measured TET1 and Nav1.6 protein in the DRG. Using lentivirus and Tet1