Phosphodiesterase inhibition restores hypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study.

• Tác giả: Damian M Bailey, Thomas A Calverley, James M Coulson, Tony G Dawkins, Lewis Fall, Angelo Iannetelli, Ifan Lewis, Christopher J Marley, Thomas S Owens, Benjamin S Stacey, Mike Stembridge, Hayato Tsukamoto
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 642072

Tóm tắt

To what extent sildenafil, a selective inhibitor of the type-5 phosphodiesterase modulates systemic redox status and cerebrovascular function during acute exposure to hypoxia remains unknown. To address this, 12 healthy males (aged 24 ± 3 y) participated in a randomized, placebo-controlled crossover study involving exposure to both normoxia and acute (60 min) hypoxia (Fi