Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis.

• Tác giả: Kwang-Hyun Cho, Youngwon Cho, Jeong-Ryeol Gong, Seoyoon D Jeong, Hwang-Phill Kim, Tae-You Kim, Dongkwan Shin
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 642161

Tóm tắt

A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single-cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single-cell transcriptome of patient-derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.