With the increase of esthetic procedures using hyaluronic acid injections, the risk of complications also increases. Due to their complexity, interdisciplinary treatment is often necessary. In recent months, three cases have been treated on an interdisciplinary basis at Leipzig University Medical Center. This motivated us to develop a joint recommendation for action in co-operation with the departments of dermatology, plastic surgery, oral and maxillofacial surgery, ENT (ear, nose and throat), ophthalmology, and neurology.