Galectins, a family of carbohydrate-binding proteins, regulate immune responses, neuroinflammation, and neurogenesis within the central nervous system (CNS). Among the 15 known galectins, galectins-1, -3, -4, -8, and -9 play significant roles in neuroinflammation and have been investigated in the context of CNS pathologies. This review synthesizes recent advancements in understanding galectins' involvement in the neurobiology of brain disorders, focusing on their interplay with signaling pathways underlying major depressive disorder (MDD). It explores their impact on neuroinflammation, neurogenesis, and brain signaling, highlighting the therapeutic potential of targeting galectins while addressing challenges in translating these findings into clinical practice. Comprehensive studies are essential to unravel the complex mechanisms of galectin-mediated pathways and unlock their full potential for managing neuropsychiatric conditions.