Cardiac health, type I collagen, and aging in the

• Tác giả: Erin M Carter, Isabel M Chapman, Tara K Crawford, Chloe E Derocher, Maike Krenz, Brittany N Lafaver, Li Lee, Lawrence F Levin, Lixin Ma, Ali McAllister-Day, Charlotte L Phillips, Cathleen L Raggio, Krish Sardesai, Julian A Vallejo, Michael J Wacker
• Ngôn ngữ: eng
• Ký hiệu phân loại: 663.17 Aging
• Thông tin xuất bản: United States : American journal of physiology. Heart and circulatory physiology , 2025
• Bộ sưu tập: NCBI
• ID: 642378

Tóm tắt

Osteogenesis imperfecta (OI) is a heritable connective tissue disorder with marked skeletal fragility and increased recognition as a pleiotropic type I collagenopathy. The impact of OI-causing gene variants on cardiac health and lifespan is just beginning to be understood. To begin to investigate cardiac manifestations of OI-causing type I collagen variants, we utilized the osteogenesis imperfecta murine (