Due to the unique advantages of mimicking natural enzymes, nanozymes have received ever-growing interest in a wide range of fields including analytical chemistry in the past two decades. Exploring novel kinds of nanozymes with efficient active sites has always been one of the most important and hot topics in nanozyme-related research so far, especially in portable monitors. Herein, zeolitic imidazolate framework-8 (ZIF-8) incorporated with an organometallic iridium(III) complex as a new active site denoted as Irppy-ZIF-8 obtained