Whole-genome sieve analysis: Identification of protective malaria antigens by leveraging allele-specific vaccine efficacy.

• Tác giả: Ankit Dwivedi, Kirsten E Lyke, Gillian Mbambo, Amed Ouattara, Ryan Scalsky, Joana C Silva, Thomas C Stabler, Shannon Takala-Harrison
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.0792 Diseases
• Thông tin xuất bản: Netherlands : Vaccine , 2025
• Bộ sưu tập: NCBI
• ID: 642601

Tóm tắt

Discovery of new protective malaria antigens will enable the development of novel vaccine formulations with potentially higher efficacy. While several high-throughput experimental approaches enable the identification of novel immunogens, none so far has been designed to selectively identify protective antigens. Here, we propose that sieve analysis conducted on the whole genome (SA