Harnessing near-infrared and Raman spectral sensing and artificial intelligence for real-time monitoring and precision control of bioprocess.

• Tác giả: Rong Ben, Ju Chu, Hao Gao, Kaihao Hu, Chao Li, Ali Mohsin, Lihuan Su, Xiwei Tian, Yuan Wang, Feng Xu
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Bioresource technology , 2025
• Bộ sưu tập: NCBI
• ID: 642612

Tóm tắt

Effective monitoring and control of bioprocesses are critical for industrial biomanufacturing. This study demonstrates the integration of near-infrared and Raman spectroscopy for real-time monitoring and precise control of gentamicin fermentation. The orthogonal method reduced redundant features and improved spectral model performance by 9.2-100.4 % in terms of the coefficient of determination (R