Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.

• Tác giả: Kelly M Bakulski, Scarlet Cockell, Justin A Colacino, John Dou, Lauren Y M Middleton, Vy K Nguyen, Sung Kyun Park, Chirag J Patel, Mitchell Schrank, Erika Walker, Erin B Ware
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Exposome , 2025
• Bộ sưu tập: NCBI
• ID: 642700

Tóm tắt

Cognitive impairment among older adults is a growing public health challenge and environmental chemicals may be modifiable risk factors. A wide array of chemicals has not yet been tested for association with cognition in an environment-wide association framework. In the US National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2011-2014 cross-sectional cycles, cognition was assessed using the Digit Symbol Substitution Test (DSST, scores 0-117) among participants aged 60 years and older. Concentrations of environmental chemicals measured in blood or urine were log