Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption.

• Tác giả: Madison B Blanton, Kathleen A Grant, Hami Hemati, Rupak Khadka, Jude Koura, Ilhem Messaoudi, Heather E True
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.396 Other deficiency diseases and states
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 643082

Tóm tắt

Alcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized an