HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation.

• Tác giả: Melissa-Rose Abrahams, Craig Adams, Olivia Council, Nigel Garrett, Sarah B Joseph, Salim Abdool Karim, Matthew Moeser, Jean Ntuli, Sergei Kosakovsky Pond, Amy Sondgeroth, Ean Spielvogel, Ronald Swanstrom, Ruwayhida Thebus, Lynn Tyers, Carolyn Williamson, Anna Yssel, Shuntai Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 785.13 *Trios
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 643091

Tóm tắt

 HIV-1 persists as a latent reservoir during suppressive antiretroviral therapy (ART). Viral rebound occurs upon ART interruption, posing a challenge to cure efforts. Characterizing viral populations fuelling rebound is imperative to curing HIV-1. We used longitudinal samples collected pretherapy from women in the CAPRISA 002 cohort to create an evolutionary timeline to determine the pretherapy timepoint when the rebound virus originally entered the long-lived reservoir. Participants (N=10) were untreated for an average of 5 years then on ART for an average of 2 years before viral rebound (defined as >
 1000 RNA copies/ml).