Aspergillus species are an important cause of life-threatening infections in immunocompromised patients. Those considered at high risk include patients with prolonged neutropenia, and patients who underwent bone marrow transplantation. The most common presentation of aspergillosis is invasive aspergillosis (IA) with pulmonary involvement. Microbiologic diagnosis usually involves culture or molecular tests of respiratory tract samples as blood cultures rarely grow this organism. We document an unusual case of Aspergillus fumigatus central venous line infection involving a hemodialysis catheter, with macroscopic mold growing in multiple blood cultures. The infection was probably acquired during hemodialysis treatment in Kenya, while awaiting kidney transplantation.