Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation.

• Tác giả: Qi-Pan Fan, Ming-Dong Li, Xin-Ru Li, Jia-Hao Liu, Ying-Ying Liu, Yu-Qing Qian, Yi-Fan Xu, Si-Yu Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 746.72 *Woven rugs
• Thông tin xuất bản: England : Journal of Asian natural products research , 2025
• Bộ sưu tập: NCBI
• ID: 643282

Tóm tắt

Abnormal accumulation of hepatocyte lipids is a hallmark feature of NAFLD. Ferulic acid (FA), an ingredient with antioxidant activity in Chinese herbs, can be used to treat NAFLD by activating AMPK phosphorylation. In this study, we synthesized ten acrylic acid derivatives