Dual-mode capacitive and localized surface plasmon resonance biosensor based on high-density Au nanoislands.

• Tác giả: Hyung Eun Bae, Min-Jung Kang, Moon-Ju Kim, Soonil Kwon, Jun-Hee Park, Jae-Chul Pyun, Zhiquan Song
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Biosensors & bioelectronics , 2025
• Bộ sưu tập: NCBI
• ID: 643477

Tóm tắt

A capacitive-localized plasmon surface resonance (LSPR) dual-mode biosensor was developed using gold (Au) nanoislands modified on an Au interdigitated electrode (IDE). Au nanoislands were deposited through repeated thermal dewetting to increase their packing density and enhance sensor sensitivity. The response of the capacitive sensor to antibody-antigen interactions was optimized at 0.5 Hz in phosphate-buffered saline. Modification with Au nanoislands significantly reduced the effective electrode gap of the IDE, thereby enhancing the capacitive sensitivity, as evidenced by charge-transfer resistance and electric field analysis. Computer simulations confirmed that the effective electrode gap of a 5 μm gap Au IDE with an 88.1% packing density of Au nanoislands decreased to 525.9 nm. The influence of Au nanoislands on LSPR was assessed through parameters such as λ