BACKGROUND: Addressing vaccine hesitancy is crucial, especially when considering cultural factors. This article outlines the creation of a training curriculum model designed to equip healthcare professionals with the essential knowledge, expertise, and cultural competency required to effectively promote vaccination and tackle vaccine hesitancy. METHODS: A two-round Delphi Study with 23 experts from four European countries-Spain, Greece, Romania, and Cyprus - and diverse backgrounds, based on predetermined criteria, was undertaken. The aim was to identify key topics, through purposive sampling, ensuring diversity and representativeness within the participant group. The process generated valuable insights and highlighted the significance of all statements in culturally sensitive vaccination practices. Five statements from each module were chosen as the fundamental content of the curriculum. These selections were based on mean scores, range, and median values. RESULTS: The curriculum model reflects the collective insights of experts, paving the way for improved vaccination advocacy and community engagement. It encompasses four modules based on the Papadopoulos Tilki and Taylor (PPT) model for cultural competence, each targeting specific learning objectives to enhance healthcare professionals' abilities in advocating for vaccination and providing culturally appropriate care for population groups in diverse cultural contexts. CONCLUSION: The training curriculum model emphasizes intercultural communication, empowerment, and advocacy, offering a holistic strategy for promoting vaccination acceptance. It is crucial for healthcare professionals to possess the necessary knowledge, skills, and resources to effectively protect the health and welfare of communities. This, in turn, contributes to the development of enduring, fair, and robust healthcare systems.