OBJECTIVE: To clarify the short- and long-term validity of pancreatoduodenectomy in octogenarian patients with biliary tract carcinoma. METHODS: We compared 23 and 141 patients aged ≥80 and <
80 years, who underwent pancreatoduodenectomy for biliary tract carcinoma (distal cholangiocarcinomas and ampullary carcinomas) and evaluated the relationship between age, clinicopathological factors, and surgical and oncological outcomes, especially in terms of recurrence. RESULTS: Median overall survival time of distal cholangiocarcinoma and ampullary carcinoma was 92 and 109 months ( CONCLUSIONS: Octogenarians had a shorter survival time after recurrence, resulting from low nutritional indices and a reduced rate of treatment implementation at the time of recurrence.