This study investigates the application of pyrene-based HOFs in ethyl cellulose (EC)-based food packaging films. As the environmental impact of traditional plastics becomes increasingly significant, the development of environmentally friendly food packaging materials is urgent. The study synthesized two types of HOFs, HOF-PyTTA and PFC-2, which were fabricated into EC-HOFs composite films using a solution casting method. These composite films not only demonstrate excellent biocompatibility and hemocompatibility but also exhibit significantly enhanced UV shielding effects and antioxidant properties. In particular, EC-HOF-PyTTA-1 % film shows the best UV shielding effect (70.3 %) and antioxidant performance (31.8 %), and it also possesses a fluorescence angle-dependent color change function. The study indicates that the introduction of HOFs significantly improves the mechanical properties and thermal stability of EC films, providing new insights for the green design of food packaging materials.