PURPOSE: To examine the sensitivity to change of the Healthy Aging Brain Care Monitor (HABC-M) through a longitudinal analytical comparison with reference standards. PATIENTS AND METHODS: We used longitudinal data from 120 participants in a multicenter randomized controlled trial evaluating the effectiveness of the Trauma Medical Home (TMH). We used the following reference standards: The depression and anxiety subdomains of the Hospital Anxiety and Depression Scale (HADS), the Patient-Reported Outcomes Measurement Information System Sleep Disturbance Short Form 4a (PROMIS-SF), and the Pain, Enjoyment of Life, and General Activity Scale (PEG). We assessed sensitivity to change using three longitudinal comparative analytical methods. The correlation of the HABC-M score with reference standards' scores over time, the correlation of changes in the HABC-M score with changes in reference standards' scores, and a longitudinal analysis to compare changes in the HABC-M against reference standards' known change categories. RESULTS: Throughout the six-month period, the HABC-M exhibited moderate to high correlations with the HADS (r = 0.66, p<
0.001 for the depression subdomain and r = 0.42, p<
0.001 for the anxiety subdomain), the PROMIS-SF (r = 0.57, p<
0.001), and the PEG (r = 0.47, p<
0.001). The changes in HABC-M significantly correlated with changes in reference standards at various time points. HABC-M scores were significantly different across known change categories established by the four reference standards, with standardized response mean (SRM) values ranging from 1.08 to 1.44. CONCLUSION: The HABC-M is capable of monitoring the recovery of older trauma survivors.