Foamy monocytes and atherogenesis in mice with combined hyperlipidemia and effects of antisense knockdown of apoCIII.

• Tác giả: Christie M Ballantyne, Rosanne Crooke, Xiao-Yuan Dai Perrard, Henry Dong, Zeqin Lian, Benjamin A Litchfield, Aparna Mukherjee, Adam E Mullick, Jing Ni, Veronica O'Brien, Xueying Peng, Henry J Pownall, Timothy Simmons, Scott I Simon, Huaizhu Wu, Jing Xiao, Lu Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 398.2454 Folk literature
• Thông tin xuất bản: United States : Journal of lipid research , 2025
• Bộ sưu tập: NCBI
• ID: 643801

Tóm tắt

Hypertriglyceridemia (HTG), particularly in combined hyperlipidemia, increases risk for atherosclerotic cardiovascular disease, but the underlying mechanisms remain incompletely understood. We sought to determine contributions of circulating monocytes to atherosclerosis associated with HTG in combined hyperlipidemia, created by transgenic expression of human apoCIII in Ldlr